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Study designs Laboratory school protocol (LSP)76 Laboratory school protocol (LSP)76

The application of the LSP to the development of stimulant treatments for ADHD is well documented

Uses “cycles of time” to equally expose subjects to different settings in a repeated way across the day

  •  For ADHD studies, subjects cycle between the analogue classroom and structured activities
  •  Uses age and developmentally appropriate activities and environmental modifications for preschool and school-aged children

Allows for systematic collection of information deemed to be critical in the standard clinical practice of treating disruptive behavior disorders with medication

  •  Dosing, safety, attention, behavior, and classroom productivity

Pharmacodynamic (PD) and pharmacokinetic (PK) information can be collected simultaneously

Safety measurements include pulse rate, blood pressure, electrocardiogram, and side effect ratings

The application of the LSP to the development of stimulant treatments for ADHD is well documented

Uses “cycles of time” to equally expose subjects to different settings in a repeated way across the day

 For ADHD studies, subjects cycle between the analogue classroom and structured activities
 Uses age and developmentally appropriate activities and environmental modifications for preschool and school-aged children

Allows for systematic collection of information deemed to be critical in the standard clinical practice of treating disruptive behavior disorders with medication

 Dosing, safety, attention, behavior, and classroom productivity

Pharmacodynamic (PD) and pharmacokinetic (PK) information can be collected simultaneously

Safety measurements include pulse rate, blood pressure, electrocardiogram, and side effect ratings

*Also called the analogue laboratory classroom

References

76. Wigal SB, Wigal TL. The Laboratory School Protocol: Its origin, use, and new applications. Journal of Attention Disorders. 2006;10(1):92-111.